Surface soil moisture estimate from Sentinel-1 and Sentinel-2 data in agricultural fields in areas of high vulnerability to climate variations: the Marche region (Italy) case study

Surface soil moisture is a key hydrologic state variable that greatly influences the global environment and human society. Its significant decrease in the Mediterranean region, registered since the 1950s, and expected to continue in the next century, threatens soil health and crops. Microwave remote sensing techniques are becoming a key tool for the implementation of climate-smart agriculture, as a means for surface soil moisture retrieval that exploits the correlation between liquid water and the dielectric properties of soil. In this study, a workflow in Google Earth Engine was developed to estimate surface soil moisture in the agricultural fields of the Marche region (Italy) through Synthetic Aperture Radar data. Firstly, agricultural areas were extracted with both Sentinel-2 optical and Sentinel-1 radar satellites, investigating the use of Dual-Polarimetric Entropy-Alpha decomposition's bands to improve the accuracy of radar data classification. The results show that Entropy and Alpha bands improve the kappa index obtained from the radar data only by 4% (K = 0.818), exceeding optical accuracy in urban and water areas. However, they still did not allow to reach the overall optical accuracy (K = 0.927). The best classification results are reached with the total dataset (K = 0.949). Subsequently, Water Cloud and Tu Wien models were implemented on the crop areas using calibration parameters derived from literature, to test if an acceptable accuracy is reached without in situ observation. While the first model’s accuracy was inadequate (RMSD = 12.3), the extraction of surface soil moisture using Tu Wien change detection method was found to have acceptable accuracy (RMSD = 9.4)

Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF-platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage

Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that the rare complex allele [G576V;R668C] is associated with a milder disease via a gain-of-function mechanism. Conversely, CFTR ultra-rare alleles with reduced function are associated with disease severity either alone (dominant disorder) or with another hypomorphic allele in the second chromosome (recessive disorder) with a global residual CFTR activity between 50 to 91%. Furthermore, we characterized novel CFTR complex alleles, including [A238V;F508del], [R74W;D1270N;V201M], [I1027T;F508del], [I506V;D1168G], and simple alleles, including R347C, F1052V, Y625N, I328V, K68E, A309D, A252T, G542*, V562I, R1066H, I506V, I807M, which lead to a reduced CFTR function and thus, to more severe COVID-19. In conclusion, CFTR genetic analysis is an important tool in identifying patients at risk of severe COVID-19

Francia y la Guerra de la Independencia en 1808 (de Bailén a Chamartín): la información y la acción

Ann. It. Med. Int